The ACARE LevelUp Webinar series will consist of 6 webinars that have a 50-minute lecture with 10-min question and answer sessions. They will be hosted by some of the most esteemed physicians in the angioedema field.

These 1 hour webinars will deal with different questions and topics, which include but are not limited to guideline recommendations and updates, recent insights from publications, advances in our understanding of angioedema and the comorbidities that go along with it, biomarkers in angioedema and the biology of mast cells and the contact system including C1 inhibitor, kallikrein, bradykinin and its receptors and many more.

REGISTER NOW for Webinar 8: UNDERSTANDING THE DYNAMICS OF TRIGGERS AND PRODROMES IN HEREDITARY ANGIOEDEMA

MAY 7TH, 2025 | 2:00-3:00 pm CET

Applied for EACCME® accreditation with 1 CME Point

Agenda

Introduction

Assistant Professor Dr. Ankur Jindal

Postgraduate Institute of Medical Education and Research, Chandigar, India

TALK 1: The current concepts behind triggers in patients with HAE: how to identify and how to manage?

Talk 15’ | Q&A 3’

Prof. Dr. Teresa Caballero, MD, PhD

Hospital Universitario La Paz, Madrid, Spain

TALK 2: Clinical implications of identification of prodromes in patients with HAE

Talk 15’ | Q&A 3’

Dr. Avner Reshef

Barzilai University Hospital, Ashkelon, Israel

TALK 3: Changes in prodromal signs in patients during the use of modern LTP

Talk 15’ | Q&A 3’

Dr. Robin Lochbaum

UIm University Hospital, Ulm, Germany

Closing remarks

Assistant Professor Dr. Ankur Jindal


REGISTER NOW for Webinar 9: COMORBIDITIES IN HAE

INCLUDING RISK OF THROMBOSIS AND AUTOIMMUNITY

JULY 10TH, 2025 | 2:00-3:00 pm CET

Applied for EACCME® accreditation with 1 CME Point

Agenda

Introduction

Dr. Thomas Buttgereit

Charité – Universitätsmedizin Berlin, Institute of Allergology IFA, Fraunhofer ITMP,

Immunology and Allergology IA, Berlin, Germany

TALK 1: Comorbidities in C1 deficiency – results from an Italian survey

Talk 15’ | Q&A 3’

Dr. Andrea Zanichelli

University of Milan, I.R.C.C.S. Policlinico San Donato, Milan, Italy

TALK 2: The power of disease registries: What does the Swedish HAE registry tell us about comorbidities?

Talk 15’ | Q&A 3’

Dr. Linda Sundler Björkman

Lund University, Lund, Sweden

TALK 3: HAE and thromboembolism – is there a link and why?

Talk 15’ | Q&A 3’

Assistant Professor Dr. Steven P Grover

UNC Blood Research Center, University of North Carolina

at Chapel Hill, Chapel Hill NC, USA

Closing remarks

Dr. Thomas Buttgereit


Webinar 1: HAE Case Reports Discussion from Diagnosis to Treatment

31st January 2024, 08:30 – 09:30 am CET.

This webinar, with a focus on HAE, is designed to enable participants to:

  • understand and apply cascade screening for HAE
  • understand challenges in diagnosing and treating HAE in the Asia-Pacific region
  • understand options for HAE prophylaxis, the risk-benefit ratio of different prophylactic options, and how to avoid/minimize risks

 

Topics and Faculty:

Introduction and Moderation: Dr. Ankur Jindal, India

The domino effect: unearthing HAE from one-to-many: Ridhima Aggarwal, India

HAE in the East: Addressing disparities in diagnosis and management: Dr. Philip Li, China

A Cautionary Tale: Hilary Longhurst, New Zealand

Q&A: All faculty

Webinar 2: HAE with normal C1 inhibitor –
How to correctly diagnose and treat this rare type of recurrent angioedema

April 4th, 2024, 4:00 – 5:00 pm CET.

In this webinar, participants will learn about the current definition and types of HAE with normal C1INH. The faculty will also discuss how to establish causality of an as yet undescribed mutation for angioedema.

Topics and Faculty:

Welcome and Moderation: Thomas Buttgereit, Germany

Evolving recognition of HAE-nC1INH: Anete S Grumach, Brazil

HAE-nC1INH – presentation of clinical cases: Thomas Buttgereit, Germany

Estimated prevalence and treatment patterns of HAE with normal C1 inhibitor – an US perspective: Marc Riedl, USA

Discussion and Q&A

Webinar 3: Actual Treatment Approach in HAE :

A Perspective from Different Continents with a Focus on Growth and Emerging Markets (GEMS)

May 14th, 2024, 2:00 – 3:00 pm CET.
Topics and Faculty

Introduction and the Indian perspective: Ankur Jindal, India

HAE in South Africa: successes and challenges: Jonny Peter, South Africa

The Moscow region perspective on closing the unmet needs in HAE Medical Care: Daria Formina, Russia

The Brazilian perspective: Luis Felipe Ensina, Brazil

Discussion and Q&A

Webinar 4:

Acquired angioedema: From bench to bedside.

July 9th, 2024, 12:00 – 1:00 pm CET.
Topics and Faculty

Moderator: Dr. Jason Fok, Australia

Welcome and Introductions: Dr. Jason Fok, Australia

Introduction and association of AAE with hematological malignancies: Dr. Danny Cohn, Netherlands

Diagnosis and clinical features of AAE-C1INH: Dr. Andrea Zanichelli, Italy

Treatment of AAE-C1INH: Dr. Delphine Gobert, France

Q&A session: All faculty, moderated by Jason Fok

Webinar 5:

Dissecting Molecular and Clinical Aspects of Normal C1-INH HAE

September 18th, 2024, 12:00 – 1:00 pm CET.

Learning objectives

1. to understand the varied clinical presentations of HAE nC1INH

2. to gain insights into complex genetics of HAE nCINH

Topics & Faculty

Welcome and Introduction: Prof. Dr. Constance Katelaris, Australia

Hereditary angioedema with normal C1 inhibitor: History, meaning, types: Prof. Dr. Marc Riedl USA

New variants and the clinical differences among HAE nC1INH : Dr. Anete S. Grumach, Brazil

Genetic testing: Prof. Emeritus Anastasios E. Germenis, Greece

Q&A session: All faculty, moderated by Constance Katelaris

Webinar 6:

PEDIGREES IN HEREDITARY ANGIOEDEMA

November 12th, 2024, 2:00 – 3:00 pm CET.

Learning objectives

In this webinar, we delve into the importance and intricate process of constructing pedigrees for patients diagnosed with Hereditary Angioedema (HAE).

Join us as we explore the indispensable role of pedigrees in identifying familial patterns of HAE and learn practical strategies for effectively screening families.

 

Faculty & Topics

Welcome and Introduction (5 minutes)

Carolina Vera Ayala

Charité –Universitätsmedizin Berlin, Institute of Allergology,

Berlin, Germany

Constructing pedigrees for patients diagnosed with Hereditary Angioedema (HAE): History (15 minutes)

Dr. Andreas Recke

Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

Clinical genetics (15 minutes)

Dr. Gašper Markelj

Ljubljana University Medical Centre, Ljubljana, Slovenia

What to do before and what to expect at an appointment with a genetic counselor? (15 minutes)

Dr. Roger Colobran Oriol

Hospital Universitari Vall d’Hebron (HUVH), Vall d’Hebron Institut

de Recerca (VHIR), Jeffrey Modell Foundation Diagnostic and

Research Center for Primary Immunodeficiencies (Barcelona), Spain

Webinar 7: ADVANCEMENTS IN GENE THERAPIES: FOCUS ON CRISPR AND HEREDITARY ANGIOEDEMA TREATMENT

MARCH 20TH, 2025 | 10:00-11:00 am CET

Applied for accreditation EACCME® with 1 CME Point

 

Agenda:

Welcoming words and introduction

Prof. Dr. Costance Katelaris

Western Sydney University & Campbelltown Hospital, Sydney, Australia

TALK 1: The Current HAE Treatment Landscape: How and where does gene editing of (pre)kallikrein fit?

Prof. Dr. Marc Riedl

University of California, San Diego, California, USA

TALK 2: CRISPR technology: what is it and how does it work?

Prof. Dr. Danny Cohn

Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands

TALK 3: Results from the clinical trials in HAE using CRISPR technology so far and the current status

Hon. Associate Professor Dr. Hilary Longhurst

University of Auckland and Department of Immunology, Auckland City Hospital, New Zealand

Closing remarks

Prof. Dr. Constance Katelaris

Western Sydney University & Campbelltown Hospital, Sydney, Australia