ACARE LevelUp Webinar series

Consist of 6 webinars that have a 50-minute lecture with 10-min question and answer sessions. They will be hosted by some of the most esteemed physicians in the angioedema field.

  • Guideline
  • Recommendations and updates
  • Recent insights from publications
  • Advances in our understanding of angioedema and the comorbidities that go along with it
  • Biomarkers in angioedema and the biology of mast cells and the contact system including C1 inhibitor
  • Kallikrein
  • Bradykinin and its receptors
  • And many more.

Webinar 11 / Identifying and Addressing Unmet Needs in Hereditary Angioedema – a global physician perspective REGISTRER NOW

NOVEMBER 11TH, 2025 | 9:30-10:30 pm CET

An application has been made to the UEMS EACCME® for CME/CPD accreditation of this event

AGENDA

  • Welcome and introduction

    Dr. Thomas Buttgereit / Charité – University Hospital Berlin, Institute of Allergology IFA; Fraunhofer IMP, Immunology and Allergology IA, Berlin, Germany

  • TALK 1 | The North American perspective

    Assistant Prof. Dr. Adil Adatia – University of Alberta in Edmonton, Alberta, Canada

  • TALK 2 | The South American perspective

    Dr. Anete S. Grumach – University Center FMABC, Medical School, São Paulo, Santo André, Brazil

  • TALK 3 | The APAC perspective

    Prof. Dr. Philip Li – The University of Hong Kong, China

  • Closing Marks

    Dr. Thomas Buttgereit / Charité – University Hospital Berlin, Institute of Allergology IFA; Fraunhofer IMP, Immunology and Allergology IA, Berlin, Germany

Webinar 10 / Advancing Treatment Options in Hereditary Angioedema: New Frontiers in Oral On-Demand Therapy–REGISTRER NOW

SEPTEMBER 24TH, 2025 | 9:30-10:30 pm CET

An application has been made to the UEMS EACCME® for CME/CPD accreditation of this event

AGENDA

  • Welcome and introduction

    Prof. Dr. Constance Katelaris – Western Sydney University & Campbelltown Hospital, Sydney, Australia

  • TALK 1 | The Need for Oral On-Demand Therapies in Hereditary Angioedema: Addressing Gaps Despite Effective Prophylaxis

    Hon. Associate Professor Dr. Hilary Longhurst – University of Auckland and Department of Immunology, Auckland City Hospital, New Zealand

  • TALK 2 | Burden of Injectable On-Demand Treatments: Understanding Patient Preferences and Challenges

    Dr. Marcin Stobiecki – The University Hospital in Krakow , Krakow, Poland

  • TALK 3 | Emerging Oral Therapies in HAE: A Review of Clinical Trials with Sebetralstat and Deucrictibant

    Assistant Prof. Dr. Anna Valerieva Medical University of Sofia, Sofia, Bulgaria

  • Closing Marks

    Prof. Dr. Constance Katelaris Western Sydney University & Campbelltown Hospital, Sydney, Australia


Webinar 9 / Comorbidities in HAE including risk of Thrombosis and Autoimmunity – REGISTRER NOW

JULY 10TH, 2025 | 2:00-3:00 pm CET

An application has been made to the UEMS EACCME® for CME/CPD accreditation of this event

AGENDA

  • INTRODUCTION & MODERATION 5’

    Dr. Thomas Buttgereit – Charité, Universitätsmedizin Berlin, Institute of Allergology IFA, Fraunhofer ITMP, Immunology and Allergology IA, Berlin, Germany

  • TALK 1 | Comorbidities in C1 deficiency – results from an Italian survey

    Dr. Andrea Zanichelli – University of Milan, I.R.C.C.S. Policlinico San Donato, Milan, Italy

  • TALK 2 | The power of disease registries: What does the Swedish HAE registry tell us about comorbidities?

    Dr. Linda Sundler Björkman – Lund University, Lund, Sweden

  • TALK 3 | HAE and thromboembolism – is there a link and why?

    Dr. Robin Lochbaum – UIm University Hospital, Ulm, Germany

  • Closing Marks
    Dr. Thomas Buttgereit


Webinar 8 / Understanding the dynamics of triggers and prodromes in Hereditary Angioedema

MAY 7TH, 2025 | 2:00-3:00 pm CET

Learning objective:

  • This webinar aims to provide a comprehensive overview of the current ad­vancements in the endotyping of chronic urticaria (CU).
  • Experts in the field will discuss the biological and immunological underpin­nings of CU, the significance of endotypes in guiding personalized treatment approaches, and the latest research insights into disease mechanisms.


TOPICS AND FACULTY

  • INTRODUCTION & MODERATION 5’

    Assistant Professor Dr. Ankur Jindal – Postgraduate Institute of Medical Education and Research, Chandigar, India

  • TALK 1 | The current concepts behind triggers in patients with HAE: how to identify and how to manage?
    Prof. Dr. Teresa Caballero, MD, PhD – Hospital Universitario La Paz, Madrid, Spain
  • TALK 2 | Clinical implications of identification of prodromes in patients with HAEThe power of disease registries: What does the Swedish HAE registry tell us about comorbidities?
    Dr. Avner Reshef – Barzilai University Hospital, Ashkelon, Israel
  • TALK 3 | Changes in prodromal signs in patients during the use of modern LTPHAE and thromboembolism – is there a link and why?
    Dr. Robin Lochbaum – UIm University Hospital, Ulm, Germany
  • Closing Marks
    Assistant Professor Dr. Ankur Jindal

Webinar 7 / Advancements in genetherapies: Focus on Crispr and Hereditary Angioedema Treatment

MARCH 20TH, 2025 | 10:00-11:00 am CET

TOPICS AND FACULTY

  • Welcoming words and introduction

    Prof. Dr. Costance Katelaris – Western Sydney University & Campbelltown Hospital, Sydney, Australia

  • TALK 1: The Current HAE Treatment Landscape: How and where does gene editing of (pre)kallikrein fit?
    Prof. Dr. Marc Riedl – University of California, San Diego, California, USA
  • TALK 2: CRISPR technology: what is it and how does it work?
    Prof. Dr. Danny Cohn – Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands
  • TALK 3: Results from the clinical trials in HAE using CRISPR technology so far and the current status
    Hon. Associate Professor Dr. Hilary Longhurst – University of Auckland and Department of Immunology, Auckland City Hospital, New Zealand

  • Closing remarks
    Prof. Dr. Constance Katelaris – Western Sydney University & Campbelltown Hospital, Sydney, Australia

Webinar 6 / Pedigrees in Hereditary Angioedema

NOVEMBER 12th, 2024 | 2:00 – 3:00 pm CET.

Learning objectives:

  • To understand the varied clinical presentations of HAE nC1INH
  • To gain insights into complex genetics of HAE nCINH

TOPICS AND FACULTY

  • Welcome and Introduction (5 minutes)

    Carolina Vera Ayala, Charité –Universitätsmedizin Berlin, Institute of Allergology, Berlin, Germany

  • Constructing pedigrees for patients diagnosed with Hereditary Angioedema (HAE): History (15 minutes)
    Dr. Andreas Recke – Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

  • Clinical genetics (15 minutes)
    Dr. Gašper Markelj – Ljubljana University Medical Centre, Ljubljana, Slovenia

  • What to do before and what to expect at an appointment with a genetic counselor? (15 minutes)
    Dr. Roger Colobran Oriol – Hospital Universitari Vall d’Hebron (HUVH), Vall d’Hebron Institut de Recerca (VHIR), Jeffrey Modell Foundation Diagnostic and Research Center for Primary Immunodeficiencies (Barcelona), Spain

Webinar 5 / Dissecting Molecular and Clinical Aspects of Normal C1-INH HAE

SEPTEMBER 18th, 2024 | 12:00 – 1:00 pm CET.

Learning objectives:

  • To understand the varied clinical presentations of HAE nC1INH
  • To gain insights into complex genetics of HAE nCINH

TOPICS AND FACULTY

  • Welcome and Introduction:

    Prof. Dr. Constance Katelaris, Australia

  • Hereditary angioedema with normal C1 inhibitor:
    History, meaning, types:
    Prof. Dr. Marc Riedl USA

  • New variants and the clinical differences among HAE nC1INH
    Dr. Anete S. Grumach, Brazil
  • Genetic testing
    Prof. Emeritus Anastasios E. Germenis, Greece
  • Q&A session
    All faculty, moderated by Constance Katelaris

Webinar 4 / Acquired angioedema: From bench to bedside.

JULY 9th, 2024 | 2:00 – 3:00 pm CET.

TOPICS AND FACULTY

  • Moderator
    Dr. Jason Fok, Australia
  • Introduction and association of AAE with hematological malignancies
    Dr. Danny Cohn, Netherlands
  • Diagnosis and clinical features of AAE-C1INH
    Dr. Andrea Zanichelli, Italy
  • Treatment of AAE-C1INH
    Dr. Delphine Gobert, France
  • Q&A session
    All faculty, moderated by Jason Fok

Webinar 3 / Actual Treatment Approach in HAE : A Perspective from Different Continents with a Focus on Growth and Emerging Markets (GEMS)

MAY 14th, 2025 | 2:00 – 3:00 pm CET.

TOPICS AND FACULTY

  • Introduction and the Indian perspective:
    Ankur Jindal, India

  • HAE in South Africa: successes and challenges:
    Jonny Peter, South Africa
  • The Moscow region perspective on closing the unmet needs in HAE Medical Care:
    Daria Formina, Russia
  • The Brazilian perspective:
    Luis Felipe Ensina, Brazil
  • Discussion and Q&A

Webinar 2 / HAE with normal C1 inhibitor – How to correctly diagnose and treat this rare type of recurrent angioedema

APRIL 4th, 2025 | 4:00 – 5:00 pm CET.

In this webinar, participants will learn about the current definition and types of HAE with normal C1INH. The faculty will also discuss how to establish causality of an as yet undescribed mutation for angioedema.


TOPICS AND FACULTY

  • Welcome and Moderation
    Thomas Buttgereit, Germany

  • Evolving recognition of HAE-nC1INH
    Anete S Grumach, Brazil

  • HAE-nC1INH – presentation of clinical cases
    Thomas Buttgereit, Germany
  • Estimated prevalence and treatment patterns of HAE with normal C1 inhibitor – an US perspective
    Marc Riedl, USA
  • Discussion and Q&A

Webinar 1 / HAE Case Reports Discussion from Diagnosis to Treatment

JANUARY 31tst, 2024 | 4:00 – 5:00 pm CET.

In this webinar, participants will learn about the current definition and types of HAE with normal C1INH. The faculty will also discuss how to establish causality of an as yet undescribed mutation for angioedema.

TOPICS AND FACULTY

  • Introduction and Moderation
    Dr. Ankur Jindal, India
  • The domino effect: unearthing HAE from one-to-many: Ridhima Aggarwal, India
  • HAE in the East: Addressing disparities in diagnosis and management
    Dr. Philip Li, China
  • A Cautionary Tale
    Hilary Longhurst, New Zealand
  • Q&A
    All faculty