{"id":483,"date":"2022-06-14T09:10:27","date_gmt":"2022-06-14T07:10:27","guid":{"rendered":"https:\/\/acare-network.com\/?post_type=avada_portfolio&#038;p=483"},"modified":"2023-01-31T14:18:32","modified_gmt":"2023-01-31T13:18:32","slug":"imagine","status":"publish","type":"avada_portfolio","link":"https:\/\/acare-network.com\/project\/imagine\/","title":{"rendered":"IMAGINE"},"content":{"rendered":"<div class=\"et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<h3>ldentification of mutations in genes of patients with recurrent idiopathic and hereditary angioedema<\/h3>\n<\/div>\n<\/div>\n<div class=\"et_pb_module et_pb_text et_pb_text_1 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<p>This explorative international, multi-center, study aims to identify known and novel mutations in patients with bradykinin-mediated recurrent angioedema, by use of dried blood spot analysis. We hope this project will spread globally and to help improve patient care.<\/p>\n<p>IMAGINE is a project of the GA2LEN HAEi network of Angioedema Centers of Reference and Excellence (ACARE). The ACARE network encourages all of its member physicians as well as non-ACARE physicians who treat patients with HAE to participate in this project.<\/p>\n<\/div>\n<\/div>\n<div class=\"et_pb_module et_pb_text et_pb_text_2 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<p><strong>Study type:<\/strong><\/p>\n<ul>\n<li>Questionnaire (physician and patient)<\/li>\n<li>Whole genome sequencing (EDTA blood) via dried blood spot cards<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div class=\"et_pb_module et_pb_text et_pb_text_3 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<p><strong>Aims:<\/strong><br \/>\n<em>Primary Objective:<\/em>\u00a0To identify genetic mutations and biomarkers in clinically well characterized patients with recurrent idiopathic angioedema in order to gain more insights into the pathomechanisms and genetic drivers of rare forms of angioedema.<\/p>\n<p><em>Secondary Objectives:<\/em>\u00a0To evaluate correlations between clinical manifestations of recurrent idiopathic angioedema and mutations and biomarkers.<\/p>\n<\/div>\n<\/div>\n<div class=\"et_pb_module et_pb_text et_pb_text_4 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<p><strong>Project lead:<br \/>\n<\/strong>Thomas Buttgereit and Markus Magerl<\/p>\n<\/div>\n<\/div>\n<div class=\"et_pb_module et_pb_text et_pb_text_5 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<p><strong>Steering Committee:<\/strong><br \/>\nKiran Godse, Asli Gelincik, Margarida Gon\u00e7alo, Marcus Maurer, Anete S Grumach, Marc Riedl, Yuxiang Zhi<\/p>\n<\/div>\n<\/div>\n<div class=\"et_pb_module et_pb_text et_pb_text_8 et_pb_text_align_left et_pb_bg_layout_light\">\n<div class=\"et_pb_text_inner\">\n<p><strong>For more information please have a look into our member area or contact the project lead:\u00a0<\/strong><a title=\"thomas.buttgereit@charite.de\" href=\"mailto:thomas.buttgereit@charite.de\">thomas.buttgereit@charite.de<\/a><\/p>\n<p>Please also see the follow-up project <a href=\"https:\/\/acare-network.com\/project\/imagine-2-0\/\" target=\"_blank\" rel=\"noopener\">IMAGINE 2.0<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>ldentification of mutations in genes of patients with recurrent idiopathic [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"portfolio_category":[14],"portfolio_skills":[],"portfolio_tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.2 - 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